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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 2
1993 1
1996 2
1997 1
1998 2
1999 1
2001 1
2002 3
2003 2
2004 10
2005 9
2006 5
2007 7
2008 16
2009 20
2010 23
2011 19
2012 19
2013 19
2014 27
2015 33
2016 18
2017 12
2018 10
2019 9
2020 20
2021 31
2022 26
2023 14
2024 4

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306 results

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Page 1
An autoimmune stem-like CD8 T cell population drives type 1 diabetes.
Gearty SV, Dündar F, Zumbo P, Espinosa-Carrasco G, Shakiba M, Sanchez-Rivera FJ, Socci ND, Trivedi P, Lowe SW, Lauer P, Mohibullah N, Viale A, DiLorenzo TP, Betel D, Schietinger A. Gearty SV, et al. Nature. 2022 Feb;602(7895):156-161. doi: 10.1038/s41586-021-04248-x. Epub 2021 Nov 30. Nature. 2022. PMID: 34847567 Free PMC article.
CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance mechanisms in autoreactive CD8 T cells(1). How autoimmune T cell populations arise and are sustained, and the molecular programmes defining the autoimmune T cell state, …
CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance mechanisms in autoreactive CD8 T cells(1). …
Hallmarks of CD8(+) T cell dysfunction are established within hours of tumor antigen encounter before cell division.
Rudloff MW, Zumbo P, Favret NR, Roetman JJ, Detrés Román CR, Erwin MM, Murray KA, Jonnakuti ST, Dündar F, Betel D, Philip M. Rudloff MW, et al. Nat Immunol. 2023 Sep;24(9):1527-1539. doi: 10.1038/s41590-023-01578-y. Epub 2023 Aug 3. Nat Immunol. 2023. PMID: 37537361 Free PMC article.
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven by chronic T cell antigen receptor (TCR) stimulation over days to weeks. However, we …
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to halt cancer progression. TST dysfunction, a …
TOX is a critical regulator of tumour-specific T cell differentiation.
Scott AC, Dündar F, Zumbo P, Chandran SS, Klebanoff CA, Shakiba M, Trivedi P, Menocal L, Appleby H, Camara S, Zamarin D, Walther T, Snyder A, Femia MR, Comen EA, Wen HY, Hellmann MD, Anandasabapathy N, Liu Y, Altorki NK, Lauer P, Levy O, Glickman MS, Kaye J, Betel D, Philip M, Schietinger A. Scott AC, et al. Nature. 2019 Jul;571(7764):270-274. doi: 10.1038/s41586-019-1324-y. Epub 2019 Jun 17. Nature. 2019. PMID: 31207604 Free PMC article.
Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the functional effector or memory T cell states(1-6). ...Expression of TOX is driven by chronic T cell receptor stimulation and NFAT activation. Ectopic expression of TOX …
Tumour-specific CD8 T cell dysfunction is a differentiation state that is distinct from the functional effector or memory T ce …
TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion.
Shakiba M, Zumbo P, Espinosa-Carrasco G, Menocal L, Dündar F, Carson SE, Bruno EM, Sanchez-Rivera FJ, Lowe SW, Camara S, Koche RP, Reuter VP, Socci ND, Whitlock B, Tamzalit F, Huse M, Hellmann MD, Wells DK, Defranoux NA, Betel D, Philip M, Schietinger A. Shakiba M, et al. J Exp Med. 2022 Feb 7;219(2):e20201966. doi: 10.1084/jem.20201966. Epub 2021 Dec 22. J Exp Med. 2022. PMID: 34935874 Free PMC article.
T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed a cancer mouse model in which tumor-specific CD8 T cells (TST cells) encounter tumor antigens with varying TCR signal strength. ...
T cell receptor (TCR) signal strength is a key determinant of T cell responses. We developed a cancer mouse model in which tum …
Expression of Concern.
Listed NA. Listed NA. Eur Rev Med Pharmacol Sci. 2024 Jan;28(2):445. doi: 10.26355/eurrev_202401_35160. Eur Rev Med Pharmacol Sci. 2024. PMID: 38305629 Free article.
DOI: 10.26355/eurrev_202312_34697-PMID: 38112953. . M.C. Medori, K. Donato, L. Stuppia, T. Beccari, M. Dundar, R.S. Marks, S. Michelini, E. Borghetti, C. ...K. Donato, M.C. Medori, A. Macchia, S. Cecchin, M.R. Ceccarini, T. Beccari, V. Gatta, L. Stuppia, V. B …
DOI: 10.26355/eurrev_202312_34697-PMID: 38112953. . M.C. Medori, K. Donato, L. Stuppia, T. Beccari, M. Dundar, R.S. Marks, S. …
A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes.
Rubio-Navarro A, Gómez-Banoy N, Stoll L, Dündar F, Mawla AM, Ma L, Cortada E, Zumbo P, Li A, Reiterer M, Montoya-Oviedo N, Homan EA, Imai N, Gilani A, Liu C, Naji A, Yang B, Chong ACN, Cohen DE, Chen S, Cao J, Pitt GS, Huising MO, Betel D, Lo JC. Rubio-Navarro A, et al. Nat Cell Biol. 2023 Apr;25(4):565-578. doi: 10.1038/s41556-023-01103-1. Epub 2023 Mar 16. Nat Cell Biol. 2023. PMID: 36928765 Free PMC article.
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.
Chandran SS, Ma J, Klatt MG, Dündar F, Bandlamudi C, Razavi P, Wen HY, Weigelt B, Zumbo P, Fu SN, Banks LB, Yi F, Vercher E, Etxeberria I, Bestman WD, Da Cruz Paula A, Aricescu IS, Drilon A, Betel D, Scheinberg DA, Baker BM, Klebanoff CA. Chandran SS, et al. Nat Med. 2022 May;28(5):946-957. doi: 10.1038/s41591-022-01786-3. Epub 2022 Apr 28. Nat Med. 2022. PMID: 35484264 Free PMC article.
Here we describe a high-throughput platform combining single-cell transcriptomic and T cell receptor (TCR) sequencing to establish whether mutant PIK3CA, among the most frequently genomically altered driver oncogenes, generates an immunogenic public NeoAg. ...In patients w …
Here we describe a high-throughput platform combining single-cell transcriptomic and T cell receptor (TCR) sequencing to establish wh …
Providing care for older adults in the Emergency Department: expert clinical recommendations from the European Task Force on Geriatric Emergency Medicine.
Lucke JA, Mooijaart SP, Heeren P, Singler K, McNamara R, Gilbert T, Nickel CH, Castejon S, Mitchell A, Mezera V, Van der Linden L, Lim SE, Thaur A, Karamercan MA, Blomaard LC, Dundar ZD, Chueng KY, Islam F, de Groot B, Conroy S. Lucke JA, et al. Eur Geriatr Med. 2022 Apr;13(2):309-317. doi: 10.1007/s41999-021-00578-1. Epub 2021 Nov 5. Eur Geriatr Med. 2022. PMID: 34738224 Free PMC article. Review.
Epsilon toxin-producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege.
Ma Y, Sannino D, Linden JR, Haigh S, Zhao B, Grigg JB, Zumbo P, Dündar F, Butler D, Profaci CP, Telesford K, Winokur PN, Rumah KR, Gauthier SA, Fischetti VA, McClane BA, Uzal FA, Zexter L, Mazzucco M, Rudick R, Danko D, Balmuth E, Nealon N, Perumal J, Kaunzner U, Brito IL, Chen Z, Xiang JZ, Betel D, Daneman R, Sonnenberg GF, Mason CE, Vartanian T. Ma Y, et al. J Clin Invest. 2023 May 1;133(9):e163239. doi: 10.1172/JCI163239. J Clin Invest. 2023. PMID: 36853799 Free PMC article.
306 results